RGS11

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Regulator G-proteinske signalizacije 11
Identifikatori
SimboliRGS11; RS11
Vanjski IDOMIM: 603895 MGI: 1354739 HomoloGene: 77719 GeneCards: RGS11 Gene
Ontologija gena
Molekulska funkcija • aktivnost signalnog prenosnika
• aktivnost aktivatora GTPaze
• vezivanje G-protein beta-podjednice
Ćelijska komponenta • citoplazma
• heterotrimerni G-proteinski kompleks
• ćelijska membrana
Biološki proces • signalni put G-protein spegnutog receptora
• regulacija signalnog puta G-protein spregnutog receptora
• intracelularni prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez878650782
EnsemblENSG00000076344ENSMUSG00000024186
UniProtO94810G3X8W6
Ref. Sekv. (iRNK)NM_001286485NM_001081069
Ref. Sekv. (protein)NP_001273414NP_001074538
Lokacija (UCSC)Chr 16:
0.32 - 0.33 Mb		Chr 17:
26.2 - 26.21 Mb
PubMed pretraga[1][2]

Regulator G-proteinske signalizacije 11 je protein koji je kod ljudi kodiran RGS11 genom.[1][2]

Protein kodiran ovim genom pripada RGS (regulator G protein signalizacije) familije. Članovi RGS familije deluju kao aktivirajući proteini GTPaze na alfa podjedinicama heterotrimernih, signal-prenosećih G proteina. Ovaj protein inhibira prenos signala putem povišenja GTPazne aktivnosti G protein alfa podjedinica, čime ih dovodi u njihovu neaktivnu GDP-vezanu formu. Alternativnim splajsovanjem ovog lokusa nastaju dve transkriptne varijante koje kodiraju razlčite izoforme.[2]

Reference

  1. ↑ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). „A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits”. Proc Natl Acad Sci U S A 95 (22): 13307–12. DOI:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084. 
  2. ↑ 2,0 2,1 „Entrez Gene: RGS11 regulator of G-protein signalling 11”. 

Literatura

  • Martin J, Han C, Gordon LA, et al. (2005). „The sequence and analysis of duplication-rich human chromosome 16.”. Nature 432 (7020): 988–94. DOI:10.1038/nature03187. PMID 15616553. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Sierra DA, Gilbert DJ, Householder D, et al. (2002). „Evolution of the regulators of G-protein signaling multigene family in mouse and human.”. Genomics 79 (2): 177–85. DOI:10.1006/geno.2002.6693. PMID 11829488. 
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). „Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.”. Hum. Mol. Genet. 10 (4): 339–52. DOI:10.1093/hmg/10.4.339. PMID 11157797. 
  • Snow BE, Betts L, Mangion J, et al. (1999). „Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.”. Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. DOI:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615. 
  • Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). „Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.”. J. Neurosci. 17 (20): 8024–37. PMID 9315921. 
  • p
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Aktivirajući protein GTPaze
Monomerni
Heterotrimeni
Faktor razmene guanin nukleotida
EIF2B • Son of Sevenless • Ras-GRF1

FGD: FGD1 • FGD2 • FGD3 • FGD4

ALS2 • SIL1 • IQSEC2
Drugi
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)