USP14

Protein-coding gene in the species Homo sapiens
USP14
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2AYN, 2AYO

Identifiers
AliasesUSP14, TGT, ubiquitin specific peptidase 14, Ubp6
External IDsOMIM: 607274; MGI: 1928898; HomoloGene: 3780; GeneCards: USP14; OMA:USP14 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for USP14
Genomic location for USP14
Band18p11.32Start158,383 bp[1]
End214,629 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for USP14
Genomic location for USP14
Band18 A1|18 4.91 cMStart9,993,066 bp[2]
End10,045,119 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • tibialis anterior muscle

  • deltoid muscle

  • pons

  • thoracic diaphragm

  • trabecular bone

  • trigeminal ganglion

  • lateral nuclear group of thalamus

  • skin of hip

  • spinal ganglia
Top expressed in
  • tail of embryo

  • dorsomedial hypothalamic nucleus

  • ventromedial nucleus

  • dentate gyrus of hippocampal formation granule cell

  • epiblast

  • lateral septal nucleus

  • mammillary body

  • lateral hypothalamus

  • superior frontal gyrus

  • maxillary prominence
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • cysteine-type peptidase activity
  • proteasome binding
  • peptidase activity
  • protein binding
  • thiol-dependent deubiquitinase
  • cysteine-type endopeptidase activity
  • endopeptidase inhibitor activity
  • hydrolase activity
  • tRNA guanylyltransferase activity
Cellular component
  • membrane
  • plasma membrane
  • synapse
  • cell surface
  • proteasome complex
  • extracellular exosome
  • cytoplasm
  • cytosol
  • cytoplasmic vesicle
  • nucleus
Biological process
  • regulation of proteasomal protein catabolic process
  • regulation of chemotaxis
  • ubiquitin-dependent protein catabolic process
  • proteolysis
  • negative regulation of ER-associated ubiquitin-dependent protein catabolic process
  • chemical synaptic transmission
  • negative regulation of endopeptidase activity
  • protein deubiquitination
  • immune system process
  • innate immune response
  • tRNA 5'-end processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9097

59025

Ensembl

ENSG00000101557

ENSMUSG00000047879

UniProt

P54578

Q9JMA1

RefSeq (mRNA)

NM_005151
NM_001037334

NM_001038589
NM_021522
NM_001360884

RefSeq (protein)

NP_001032411
NP_005142

NP_001033678
NP_067497
NP_001347813

Location (UCSC)Chr 18: 0.16 – 0.21 MbChr 18: 9.99 – 10.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene.[5][6]

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

Interactions

USP14 has been shown to interact with CXCR4.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101557 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047879 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ a b "Entrez Gene: USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)".
  7. ^ Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH (Feb 2009). "Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation". J. Biol. Chem. 284 (9): 5742–52. doi:10.1074/jbc.M808507200. PMC 2645827. PMID 19106094.

Further reading

  • Wilson SM, Bhattacharyya B, Rachel RA, Coppola V, Tessarollo L, Householder DB, Fletcher CF, Miller RJ, Copeland NG, Jenkins NA (2002). "Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease". Nature Genetics. 32 (3): 420–425. doi:10.1038/ng1006. PMID 12368914. S2CID 23542012.
  • D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
  • Deshpande KL, Seubert PH, Tillman DM, Farkas WR, Katze JR (1996). "Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit". Arch. Biochem. Biophys. 326 (1): 1–7. doi:10.1006/abbi.1996.0039. PMID 8579355.
  • Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
  • Dennehey BK, Gutches DG, McConkey EH, Krauter KS (2004). "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution". Genomics. 83 (3): 493–501. doi:10.1016/j.ygeno.2003.08.017. PMID 14962675.
  • Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y (2005). "Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14". EMBO J. 24 (21): 3747–56. doi:10.1038/sj.emboj.7600832. PMC 1276716. PMID 16211010.
  • Shinji S, Naito Z, Ishiwata S, Ishiwata T, Tanaka N, Furukawa K, Suzuki H, Seya T, Matsuda A, Katsuta M, Tajiri T (2006). "Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases". Oncol. Rep. 15 (3): 539–43. doi:10.3892/or.15.3.539. PMID 16465409.
  • Crimmins S, Jin Y, Wheeler C, Huffman AK, Chapman C, Dobrunz LE, Levey A, Roth KA, Wilson JA, Wilson SM (2006). "Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14". J. Neurosci. 26 (44): 11423–31. doi:10.1523/JNEUROSCI.3600-06.2006. PMC 6674543. PMID 17079671.

External links

  • Overview of all the structural information available in the PDB for UniProt: P54578 (Ubiquitin carboxyl-terminal hydrolase 14) at the PDBe-KB.


  • v
  • t
  • e
  • 1wgg: Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)
    1wgg: Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)
  • 2ayn: Structure of USP14, a proteasome-associated deubiquitinating enzyme
    2ayn: Structure of USP14, a proteasome-associated deubiquitinating enzyme
  • 2ayo: Structure of USP14 bound to ubquitin aldehyde
    2ayo: Structure of USP14 bound to ubquitin aldehyde


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