TRIM3

TRIM3
Identifiers
Aliases	TRIM3, BERP, HAC1, RNF22, RNF97, tripartite motif containing 3
External IDs	OMIM: 605493; MGI: 1860040; HomoloGene: 21290; GeneCards: TRIM3; OMA:TRIM3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 6,448,613 bp[1] End 6,474,459 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 105,253,670 bp[2] End 105,282,778 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum mucosa of transverse colon right frontal lobe paraflocculus of cerebellum tibial nerve body of uterus right coronary artery popliteal artery tibial arteries Top expressed in cerebellar cortex neural layer of retina primary visual cortex superior frontal gyrus cerebellar vermis lobe of cerebellum dentate gyrus of hippocampal formation granule cell prefrontal cortex piriform cortex lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein C-terminus binding protein binding metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Cellular component cytoplasm endosome early endosome intracellular anatomical structure Golgi apparatus dendrite cell projection Biological process protein transport protein ubiquitination nervous system development protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10612 55992 Ensembl ENSG00000110171 ENSMUSG00000036989 UniProt O75382 Q9R1R2 RefSeq (mRNA) NM_001248006 NM_001248007 NM_006458 NM_033278 NM_033279 NM_001285870 NM_001285871 NM_001285873 NM_018880 NM_001360425 RefSeq (protein) NP_001234935 NP_001234936 NP_006449 NP_150594 NP_001272799 NP_001272800 NP_001272802 NP_061368 NP_001347354 Location (UCSC) Chr 11: 6.45 – 6.47 Mb Chr 7: 105.25 – 105.28 Mb PubMed search [3] [4]
Wikidata
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Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene.^[5][6]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.^[6]

Interactions

TRIM3 has been shown to interact with Actinin alpha 4.^[7]

TRIM3 binds to and ubiquitinates Estrogen receptor alpha (ERa) leading to receptor's stabilization.^[8]

Moreover, TRIM3 interacts with P53 which promotes the formation of K48-linked poly-ubiquitin chains and degradation.^[9]

References

Further reading