PARD6B

Protein-coding gene in the species Homo sapiens

PARD6B

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1NF3

Identifiers

Aliases

PARD6B, PAR6B, par-6 family cell polarity regulator beta

External IDs

OMIM: 608975; MGI: 2135605; HomoloGene: 23302; GeneCards: PARD6B; OMA:PARD6B - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q13.13	Start	50,731,580 bp^[1]
Band	20q13.13	End	50,756,795 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 H3	Start	167,922,924 bp^[2]
Band	2\|2 H3	End	167,943,123 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

germinal epithelium

renal medulla

retinal pigment epithelium

palpebral conjunctiva

epithelium of nasopharynx

amniotic fluid

jejunal mucosa

lower lobe of lung

mucosa of paranasal sinus

bronchial epithelial cell

Top expressed in

secondary oocyte

zygote

primary oocyte

left lung lobe

renal corpuscle

medullary collecting duct

right kidney

right lung lobe

yolk sac

epiblast

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding protein kinase C binding
Cellular component	membrane bicellular tight junction plasma membrane apical part of cell cell junction cell cortex extracellular exosome nucleus cytoplasm cytosol apical plasma membrane protein-containing complex
Biological process	regulation of cell migration axonogenesis cell division bicellular tight junction assembly cell cycle cell-cell junction assembly establishment or maintenance of cell polarity centrosome cycle regulation of cellular localization protein-containing complex assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


84612


58220

Ensembl


ENSG00000124171


ENSMUSG00000044641

UniProt


Q9BYG5


Q9JK83

RefSeq (mRNA)


NM_032521


NM_021409

RefSeq (protein)


NP_115910


NP_067384

Location (UCSC)

Chr 20: 50.73 – 50.76 Mb

Chr 2: 167.92 – 167.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.^[5]^[6]

Function

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.^[6]

Interactions

PARD6B has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124171 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044641 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c ^d Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.
^ ^a ^b "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)".
^ ^a ^b Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
^ ^a ^b Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.

Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
Hurd TW, Gao L, Roh MH, Macara IG, Margolis B (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177. S2CID 25212419.
Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S (2004). "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. Biol. 13 (9): 734–43. doi:10.1016/S0960-9822(03)00244-6. PMID 12725730. S2CID 18570360.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL (2005). "Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. Bibcode:2005PNAS..102.1339L. doi:10.1073/pnas.0409578102. PMC 547886. PMID 15677324.